Netcare 911 responded to reports of a serious collision on the N3 near Mooi River.
Reports from the scene indicate that the driver of a passenger bus lost control resulting in a rollover.
An adult female sadly died in the crash, another sustained serious injuries and forty seven other people sustained injuries ranging from minor to moderate.
All the patients were treated on scene and transported by various ambulance services to hospital for further treatment.
All necessary authorities were on scene.